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Synchrotron-based SAXS for biopharmaceuticals
Gain advanced structural insights into new drug modalities (complex therapeutics and drug-delivery systems) under formulation-relevant conditions
Building on a decade of expertise in synchrotron-based solid-state characterization, we now expand our services with:
- Synchrotron-based small-angle X-ray scattering (SAXS), enabling advanced structural insight into new biopharmaceutical drug modalities in solution, in particular macromolecules & drug delivery systems
- Small-angle neutron scattering (SANS) as a complementary technique.
How does SAXS work?
SAXS probes how X-rays scatter at small angles from particles (macromolecules, drug-delivery systems, etc.) in solution, revealing their size, shape, and overall structural organization. Because measurements are performed directly in solution, samples can be analyzed under formulation-relevant and near-physiological conditions, without crystallization or extensive preparation.
SAXS has rapidly grown as a powerful tool for the structural characterization of new drug modalities in solution over very broad ranges of dimension (0.1 – 1000 nm) and timescale.
Why synchrotron-based SAXS ?
Synchrotrons produce highly intense, collimated, and tunable X-ray beams with excellent brightness and low divergence, enabling:
Why Excelsus ?
Building on more than a decade of hands-on experience with synchrotron facilities and the expertise of highly qualified PhD-level scientists, Excelsus offers cutting-edge, customizable, and cost-effective synchrotron-based SAXS services. Our capabilities go well beyond conventional laboratory techniques, while remaining competitively priced.
We also offer SANS as a complementary technique
Small-angle neutron scattering (SANS) is a solution-phase technique closely related to SAXS, providing information on the size, shape, and assembly of biomolecules and soft-matter systems in their native environment. While SAXS probes electron density using X-rays, SANS relies on neutron interactions with atomic nuclei and enables contrast variation through isotopic substitution (e.g. H/D exchange). This makes SANS highly complementary to SAXS, allowing selective highlighting of specific components within complex systems.
Applications for new biopharmaceutical drug modalities
SAXS has become a powerful tool across the whole drug lifecycle, including for troubleshooting studies and GMP investigations during commercial production.
Our publications on advanced SAXS applications
De Caro et al. (2023), Small Angle X-Ray Scattering Data Analysis and Theoretical Modelling for the Size and Shape Characterization of Drug Delivery Systems Based on Vitamin E TPGS Micelles, J. Pharm. Sci, 112, 243.
https://doi.org/10.1016/j.xphs.2022.09.029
De Caro et al. (2024), Characterization of Surfactant Spheroidal Micelle Structure for Pharmaceutical Applications: A Novel Analytical Framework, Pharmaceutics, 16(5), 604.
https://doi.org/10.3390/pharmaceutics16050604
De Caro et al. (2025), Characterization of VitE-TPGS Micelles Linked to Poorly Soluble Pharmaceutical Compounds Exploiting Pair Distribution Function's Moments, Pharmaceutics, 17(4), 431.
https://doi.org/10.3390/pharmaceutics17040431
De Caro et al. (2026) Shannon-Sampling Approach for Structural Solution of Nano-Objects by SAXS. (submitted)
